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Comparing the effects of Bassini versus tension-free hernioplasty: 3 years’ follow-up

Yulong SHI, Zhongxue SU, Leping LI, Hongjun LIU, Changqing JING,

《医学前沿（英文）》 2010年 第4卷 第4期   页码 463-468 doi: 10.1007/s11684-010-0050-5

摘要： In order to compare the effects of Bassini and tension-free mesh hernioplasty, a total of 552 patients with inguinal hernia who were subjected to surgical treatment in our hospital were randomly divided into the following two groups: the Bassini group (=269) and the tension-free mesh group (=283). The recurrence rates, pain, discomfort, and other complications were recorded, and the causes of the complications were explored. The recurrence rate in the Bassini group was 8.9% (24/269), significantly higher than that in the tension-free repair group (2.8%, 8/283). In addition, the recurrence rates in the Bassini and tension-free groups before 2004 were 12.6% and 5.6%, respectively, which were markedly higher than the rates after 2004 (5.3% and 0.7%, respectively). The rate of post-operative discomfort and pain within the first three months was higher in the Bassini group compared to the tension-free group (25.7% 18.5%, respectively). However, there was no difference after three months in the rate of post-operative discomfort and pain, incidence of infection, or scrotal edema between the two groups. The average hospital stay in the Bassini group was longer than that in the tension-free repair group (7.6€±€1.2 4.5€±€2.2 days, respectively), but the cost was lower (4518.0€±€510 6221.3€±€578 yuan, respectively). Thus, tension-free mesh hernioplasty is indicated for most inguinal hernia patients due to the low recurrence rate, rapid recovery time, and treatment success, but the traditional Bassini procedure has lower cost and other beneficial effects and is still suitable for some patients.

关键词： hernioplasty     Bassini repair     tension-free repair     complication    

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Behavior of dam concrete under biaxial compression-tension and triaxial compression-compression-tension

WANG Huailiang, SONG Yupu

《结构与土木工程前沿（英文）》 2008年 第2卷 第4期   页码 323-328 doi: 10.1007/s11709-008-0043-5

摘要： In order to meet the requirement for nonlinear analysis and design of mass concrete structures, the deformation behavior and strength of three-graded concrete specimens 250 mm × 250 mm × 400 mm with a maximum aggregate size of 80 mm and the corresponding wet-screened concrete specimens 150 mm × 150 mm × 300 mm with a maximum aggregate size of 40 mm were studied experimentally. Specimens subjected to biaxial compression-tension (C-T) and triaxial compression-compression-tension (C-C-T) stress states. Test data indicate that both the deformation and strength of the mass concrete specimens are lower than those of the corresponding wet-screened concrete small specimens, but the initial tangent modulus of the stress-strain curve of the former is greater than that of the latter. Test results show that the wet-screened effect and size effect of the specimens under complex stress states are obvious such that these should be considered in the design of mass concrete structures. In addition, respective failure criteria for mass concrete in principal stress space and octahedron stress space are proposed.

关键词： requirement     wet-screened concrete     compression-tension     maximum aggregate     principal    

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Generation and repair of AID-initiated DNA lesions in B lymphocytes

null

《医学前沿（英文）》 2014年 第8卷 第2期   页码 201-216 doi: 10.1007/s11684-014-0324-4

摘要：

Activation-induced deaminase (AID) initiates the secondary antibody diversification process in B lymphocytes. In mammalian B cells, this process includes somatic hypermutation (SHM) and class switch recombination (CSR), both of which require AID. AID induces U:G mismatch lesions in DNA that are subsequently converted into point mutations or DNA double stranded breaks during SHM/CSR. In a physiological context, AID targets immunoglobulin (Ig) loci to mediate SHM/CSR. However, recent studies reveal genome-wide access of AID to numerous non-Ig loci. Thus, AID poses a threat to the genome of B cells if AID-initiated DNA lesions cannot be properly repaired. In this review, we focus on the molecular mechanisms that regulate the specificity of AID targeting and the repair pathways responsible for processing AID-initiated DNA lesions.

关键词： class switch recombination     somatic hypermutation     activation-induced deaminase     DNA repair     genomic instability    

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Seismic stability of earth slopes with tension crack

Yundong ZHOU, Fei ZHANG, Jingquan Wang, Yufeng GAO, Guangyu DAI

《结构与土木工程前沿（英文）》 2019年 第13卷 第4期   页码 950-964 doi: 10.1007/s11709-019-0529-3

摘要： Cracks at the crest of slopes frequently occur during earthquakes. Such cracks result from limited tension strength of the soil. A tension cut-off in Mohr-Coulomb shear strength can represent this limited strength. Presented is an extension of variational analysis of slope stability with a tension crack considering seismicity. Both translational and rotational failure mechanisms are included in a pseudo-static analysis of slope stability. Developed is a closed-form to assess the seismic stability of slopes with zero tensile strength. The results indicate that the presence of the tension crack has significant effects on the seismic stability of slopes, i.e. leading to small value of the yield acceleration. Considering soil tension strength in seismic slope analysis may lead to overestimation on the stability, as much as 50% for vertical slopes. Imposing tension crack results in transit of the critical failure mode to a straight line from a log-spiral, except for flat slopes with small soil cohesion. Under seismic conditions, large cohesion may increase the depth of crack, moving it closer to the slope.

关键词： slope stability     tension     crack     limit equilibrium     seismic effect    

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Surface tension of liquid metal: role, mechanism and application

Xi ZHAO, Shuo XU, Jing LIU

《能源前沿（英文）》 2017年 第11卷 第4期   页码 535-567 doi: 10.1007/s11708-017-0463-9

摘要： Surface tension plays a core role in dominating various surface and interface phenomena. For liquid metals with high melting temperature, a profound understanding of the behaviors of surface tension is crucial in industrial processes such as casting, welding, and solidification, etc. Recently, the room temperature liquid metal (RTLM) mainly composed of gallium-based alloys has caused widespread concerns due to its increasingly realized unique virtues. The surface properties of such materials are rather vital in nearly all applications involved from chip cooling, thermal energy harvesting, hydrogen generation, shape changeable soft machines, printed electronics to 3D fabrication, etc. owing to its pretty large surface tension of approximately 700 mN/m. In order to promote the research of surface tension of RTLM, this paper is dedicated to present an overview on the roles and mechanisms of surface tension of liquid metal and summarize the latest progresses on the understanding of the basic knowledge, theories, influencing factors and experimental measurement methods clarified so far. As a practical technique to regulate the surface tension of RTLM, the fundamental principles and applications of electrowetting are also interpreted. Moreover, the unique phenomena of RTLM surface tension issues such as surface tension driven self-actuation, modified wettability on various substrates and the functions of oxides are discussed to give an insight into the acting mechanism of surface tension. Furthermore, future directions worthy of pursuing are pointed out.

关键词： surface tension     liquid metal     soft machine     printed electronics     electrowetting     self-actuation    

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Correlation between tension softening relation and crack extension resistance in concrete

Xiufang ZHANG , Shilang XU ,

《结构与土木工程前沿（英文）》 2009年 第3卷 第3期   页码 323-329 doi: 10.1007/s11709-009-0041-2

摘要： Changes of the material fracture energy consumption with crack propagation can be described by a crack extension resistance curve, one of the fundamental fracture criteria in crack mechanics. Recently, experimental observation of the fracture behavior in concrete was used to develop a new fracture criterion, the crack extension resistance curve, to analyze crack propagation during the entire concrete fracture process. The variation of the crack extension resistance is mainly associated with the energy consumption in the fracture process zone ahead of the stress-free crack tip. The crack extension resistance is then a function of the softening curve, which is a basic mechanical property in the fracture process zone. The relationship between the softening curve and the crack extension resistance curve is then analyzed based on results of three-point bending beams tests. The results indicate that the characteristic points of the crack extension resistance curve is closely related to the characteristic point on used tension softening curve.

关键词： concrete     fracture process zone     crack extension GR resistance     tension softening curve    

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Bile duct injury repair — earlier is not better

null

《医学前沿（英文）》 2015年 第9卷 第4期   页码 508-511 doi: 10.1007/s11684-015-0418-7

摘要：

Bile duct injury is a common complication of cholecystectomy. The timing of bile duct injury repair remains controversial. A recent review conducted in France reported 39% complications and 64% failure after immediate repair in 194 patients compared with 14% complications and 8% failure after late repair in 133 patients. A national review of 139 consecutive early repairs conducted at five hepatopancreaticobiliary centers in Denmark reported 4% mortality, 36% morbidity, and 42 restrictures (30%) at a median follow-up of 102 months, and only 64 patients (46%) demonstrated uneventful short-term and long-term outcomes. Most patients with bile duct injury present with bile leak and sepsis; thus, early repair is not recommended. Percutaneous drainage of bile and endoscopic stenting are the mainstays of treatment of bile leak because they convert acute bile duct injury into a controlled external biliary fistula. The ensuing benign biliary stricture should be repaired by a biliary surgeon after a delay of 4–6 weeks once the external biliary fistula has closed.

关键词： bile duct injury     cholecystectomy     laparoscopic cholecystectomy    

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Calculation method of load distribution on pipe threaded connections under tension load

Shoujun CHEN, Lianxin GAO, Qi AN

《机械工程前沿（英文）》 2011年 第6卷 第2期   页码 241-248 doi: 10.1007/s11465-011-0219-x

摘要：

This paper presents a new calculation method that can calculate the load distribution on pipe threaded connections under tension load. On the basis of elastic mechanics, the new method was developed by analyzing each thread tooth, and a new deformation and covariant equation by making a mechanics analysis on each thread tooth was obtained. Compared with the traditional method proposed by the previous references, the new deformation and covariant equation could be used to describe the relation between the previous and the next thread tooth. By applying the new method on the sample of P-110S pipe threaded connection, the obtained results show that the load on thread tooth mainly concentrates on the four or five threads engaged and the middle teeth were not utilized well to bear the loads. The model offers a new way to calculate the loads carried on the thread teeth under tension load.

关键词： load distribution     calculation method     pipe threaded connections     tension load    

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Mobile platform for hydraulic turbine blade repair robot

GUI Zhongcheng, CHEN Qiang, SUN Zhenguo, ZHANG Wenzeng, LIU Kang

《机械工程前沿（英文）》 2008年 第3卷 第2期   页码 164-169 doi: 10.1007/s11465-008-0035-0

摘要： The wall-climbing mobile platform (MP) of a robot for repairing a hydraulic turbine blade onsite is developed. The MP is equipped with ferromagnetic adhesive devices and can work on a spatial curved surface. The contradiction between mobility and load-bearing ability is analyzed, and the problem of self-adaptation to the curved face is solved using differential-driven wheeled locomotion with ferromagnetic adhesive devices. The platform adheres to the blade surface through the force provided by the ferromagnetic devices, and a certain gap exists between the magnetic devices and the blade’s surface. A mechanism of three revolution degrees of freedom, which connects the magnetic devices with the platform’s chassis, is developed to make the platform self-adapt to the complex curved surface of the turbine blade. A proof-of-principle prototype has been manufactured, and experiments prove the success of the MP. The payload of the zero-turn-radius MP with excellent maneuverability exceeds 80 kg. The platform can automatically adapt to complex spatial surfaces, which satisfy the requirements of a hydraulic turbine blade in-situ repair robot.
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Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

《医学前沿（英文）》 2019年 第13卷 第6期   页码 730-740 doi: 10.1007/s11684-019-0687-7

摘要： GATA binding protein 3 (GATA3) and mismatch repair (MMR) deficiency contribute to the development of urothelial carcinoma. However, the combined expression of GATA3 and microsatellite instability (MSI) in upper tract urothelial carcinoma (UTUC) and its prognostic value have not been investigated. Here, we immunohistochemically stained GATA3 and MMR proteins in 108 UTUC samples. GATA3 was positive in 74 cases, and its expression was significantly lower than in adjacent benign urothelium ( <0.001). Loss of GATA3 expression was statistically associated with adverse clinicopathologic parameters, such as advanced stage, lymphovascular invasion, neural invasion, lymph node metastasis, and extensive necrosis. Cancer-specific survival (CSS, =0.028) and disease-free survival (DFS, =0.024) were significantly shorter in patients with GATA3 negative tumors than in patients with GATA3 positive tumors. The absence of MMR proteins was observed in 8.3% of the cases, and focal staining was identified in 13.0%. When using “lax criteria” which resulted in counting cases as negative where MMR staining was in fact focally positive (<5%), we found that GATA3 was inversely associated with MSI ( =0.005). Moreover, GATA3 /microsatellite stability (MS) tumors were correlated with advanced pT stage ( <0.001) and poor outcome ( =0.019 for CSS, =0.016 for DFS) compared with GATA3 /MSI ones. The GATA3 /MSI cases had unfavorable clinical outcomes compared with GATA3 /MSI cases ( =0.008 for CSS, =0.023 for DFS). This finding raises a question as to whether GATA3 interacts with MSI through the TGF- signaling pathway and regulates UTUC progression.

关键词： upper tract urothelial carcinoma     GATA binding protein 3     mismatch repair     microsatellite instability     prognosis    

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High-precision gyro-stabilized control of a gear-driven platform with a floating gear tension device

《机械工程前沿（英文）》 2021年 第16卷 第3期   页码 487-503 doi: 10.1007/s11465-021-0635-5

摘要： This study presents an improved compound control algorithm that substantially enhances the anti-disturbance performance of a gear-drive gyro-stabilized platform with a floating gear tension device. The tension device can provide a self-adjustable preload to eliminate the gap in the meshing process. However, the weaker gear support stiffness and more complex meshing friction are also induced by the tension device, which deteriorates the control accuracy and the ability to keep the aim point of the optical sensors isolated from the platform motion. The modeling and compensation of the induced complex nonlinearities are technically challenging, especially when base motion exists. The aim of this research is to cope with the unmeasured disturbances as well as the uncertainties caused by the base lateral motion. First, the structural properties of the gear transmission and the friction-generating mechanism are analyzed, which classify the disturbances into two categories: Time-invariant and time-varying parts. Then, a proportional-integral controller is designed to eliminate the steady-state error caused by the time-invariant disturbance. A proportional multiple-integral-based state augmented Kalman filter is proposed to estimate and compensate for the time-varying disturbance that can be approximated as a polynomial function. The effectiveness of the proposed compound algorithm is demonstrated by comparative experiments on a gear-drive pointing system with a floating gear tension device, which shows a maximum 76% improvement in stabilization precision.

关键词： inertially stabilized platform     floating gear tension device     nonlinear friction     disturbance compensation     proportional multiple-integral observer    

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Experimental study and field application of calcium sulfoaluminate cement for rapid repair of concrete

Yanhua GUAN, Ying GAO, Renjuan SUN, Moon C. WON, Zhi GE

《结构与土木工程前沿（英文）》 2017年 第11卷 第3期   页码 338-345 doi: 10.1007/s11709-017-0411-0

摘要： The fast-track repair of deteriorated concrete pavement requires materials that can be placed, cured, and opened to the traffic in a short period. Type III cement and Calcium Sulfoaluminate (CSA) cement are the most commonly used fast-setting hydraulic cement (FSHC). In this study, the properties of Type III and CSA cement concrete, including compressive strength, coefficient of thermal expansion (CTE) and shrinkage were evaluated. The test results indicate that compressive strength of FSHC concrete increased rapidly at the early age. CSA cement concrete had higher early-age and long term strength. The shrinkage of CSA cement concrete was lower than that of Type III cement concrete. Both CSA and Type III cement concrete had similar CTE values. Based on the laboratory results, the CSA cement was selected as the partial-depth rapid repair material for a distressed continuously reinforced concrete pavement. The data collected during and after the repair show that the CSA cement concrete had good short-term and long-term performances and, therefore, was suitable for the rapid repair of concrete pavement.

关键词： Calcium Sulfoaluminate (CSA) cement     Type III cement     coefficient of thermal expansion (CTE)     shrinkage     rapid repair    

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Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast

Xuran Chu, Chengshui Chen, Chaolei Chen, Jin-San Zhang, Saverio Bellusci, Xiaokun Li

《医学前沿（英文）》 2020年 第14卷 第3期   页码 262-272 doi: 10.1007/s11684-019-0717-5

摘要： Regeneration carries the idea of regrowing partially or completely a missing organ. Repair, on the other hand, allows restoring the function of an existing but failing organ. The recognition that human lungs can both repair and regenerate is quite novel, the concept has not been widely used to treat patients. We present evidence that the human adult lung does repair and regenerate and introduce different ways to harness this power. Various types of lung stem cells are capable of proliferating and differentiating upon injury driving the repair/regeneration process. Injury models, primarily in mice, combined with lineage tracing studies, have allowed the identification of these important cells. Some of these cells, such as basal cells, broncho-alveolar stem cells, and alveolar type 2 cells, rely on fibroblast growth factor (FGF) signaling for their survival, proliferation and/or differentiation. While pre-clinical studies have shown the therapeutic benefits of FGFs, a recent clinical trial for acute respiratory distress syndrome (ARDS) using intravenous injection of FGF7 did not report the expected beneficial effects. We discuss the potential reasons for these negative results and propose the rationale for new approaches for future clinical trials, such as delivery of FGFs to the damaged lungs through efficient inhalation systems, which may be more promising than systemic exposure to FGFs. While this change in the administration route presents a challenge, the therapeutic promises displayed by FGFs are worth the effort.

关键词： FGF     human lung     repair     regeneration     stem cells    

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悬索桥短吊索索力测试的探讨

齐东春,郭健,沈锐利

《中国工程科学》 2010年 第12卷 第7期   页码 78-83

摘要：

因难以准确确定吊索的计算长度和抗弯刚度，按照公式法计算短吊索的索力误差一般较大。以新沟河大桥悬索桥吊索索力测试为研究背景，分析了吊索的边界条件、抗弯刚度、计算索长及线密度等因素对索力测试精度的影响，表明公式法的简化假设对短吊索不适用。介绍了有限元法分析吊索索力的方法，按吊索的实际尺寸建立有限元模型，首先识别出吊索的抗弯刚度，然后建立各吊索的索力—频率对应表格，查表即可得到实测频率对应的索力。该方法应用到新沟河大桥的施工监控，证明是一种行之有效的方法。

关键词： 短吊索     索力测试     频率法     抗弯刚度     有限元法    

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Effect of natural pozzolan content on the properties of engineered cementitious composites as repair

Said CHOUCHA, Amar BENYAHIA, Mohamed GHRICI, Mohamed Said MANSOUR

《结构与土木工程前沿（英文）》 2018年 第12卷 第3期   页码 261-269 doi: 10.1007/s11709-017-0394-x

摘要：

In order to determine the effect of Natural Pozzolan (NP) content on the mechanical properties and durability characteristics on Engineered Cementitious Composites (ECC) as repair material. This study focused on the evaluation of the most factors influencing compatibility between the repair material and the base concrete including mechanicals properties such as, compressive and flexural strengths, elastic modulus, capillary absorption and drying shrinkage. The experimental results showed that natural pozzolan reduces the compressive strength and the flexural strength of ECC at all ages. The elastic modulus of ECC was remarkably lower than that of normal-strength concrete. This lower Young’s modulus is desirable for repair concrete, because it prevents the stresses induced by restrained shrinkage. In addition, the incorporation of high-volume natural pozzolan decreases significantly the coefficient of capillary absorption at long term and increases the drying shrinkage. Generally, based on the results obtained in the present experimental investigation, ECC can be used effectively as an overlay material over existing parent concrete.

关键词： natural pozzolan     engineered cementitious composites     mechanical strengths     elastic modulus     capillary absorption     drying shrinkage    

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标题 作者 时间 类型 操作

Comparing the effects of Bassini versus tension-free hernioplasty: 3 years’ follow-up

Yulong SHI, Zhongxue SU, Leping LI, Hongjun LIU, Changqing JING,

期刊论文

Behavior of dam concrete under biaxial compression-tension and triaxial compression-compression-tension

WANG Huailiang, SONG Yupu

期刊论文

Generation and repair of AID-initiated DNA lesions in B lymphocytes

null

期刊论文

Seismic stability of earth slopes with tension crack

Yundong ZHOU, Fei ZHANG, Jingquan Wang, Yufeng GAO, Guangyu DAI

期刊论文

Surface tension of liquid metal: role, mechanism and application

Xi ZHAO, Shuo XU, Jing LIU

期刊论文

Correlation between tension softening relation and crack extension resistance in concrete

Xiufang ZHANG , Shilang XU ,

期刊论文

Bile duct injury repair — earlier is not better

null

期刊论文

Calculation method of load distribution on pipe threaded connections under tension load

Shoujun CHEN, Lianxin GAO, Qi AN

期刊论文

Mobile platform for hydraulic turbine blade repair robot

GUI Zhongcheng, CHEN Qiang, SUN Zhenguo, ZHANG Wenzeng, LIU Kang

期刊论文

Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

期刊论文

High-precision gyro-stabilized control of a gear-driven platform with a floating gear tension device

期刊论文

Experimental study and field application of calcium sulfoaluminate cement for rapid repair of concrete

Yanhua GUAN, Ying GAO, Renjuan SUN, Moon C. WON, Zhi GE

期刊论文

Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast

Xuran Chu, Chengshui Chen, Chaolei Chen, Jin-San Zhang, Saverio Bellusci, Xiaokun Li

期刊论文

悬索桥短吊索索力测试的探讨

齐东春,郭健,沈锐利

期刊论文

Effect of natural pozzolan content on the properties of engineered cementitious composites as repair

Said CHOUCHA, Amar BENYAHIA, Mohamed GHRICI, Mohamed Said MANSOUR

期刊论文